NIH Guidelines – Section III
Levels of Review

IBC, RAC review, and NIH Director review and approval

Experiments that compromise the control of disease agents in medicine through deliberate transfer of a drug resistance trait

III-A

IBC approval and NIH review for containment determinations

Experiments conducted with a recombinant DNA modified restricted agent in a whole animal

III-B

IBC and IRB approval and NIH review before research participant enrollment

Not applicable

III-C

IBC approval before initiation

Creating stable germline alterations of an animal’s genome, or testing viable rDNA modified microorganisms on whole animals, where BL-2 containment or greater is necessary

III-D

IBC notice at initiation

Creating stable germline alterations of rodents using recombinant DNA when these experiments require only BL-1 containment

III-E

Exempt from the NIH Guidelines. IBC registration is not required if experiment not covered by Sections III-A, III-B, III-C

Purchase or transfer of transgenic rodents

III-F